Fall 2011 Nutraceutical Manufacturing Trends

Fall 2011 Nutraceutical Manufacturing Trends

Fall 2011 Supplement Manufacturing TrendsFall is associated with cooler temperatures and higher atmospheric pressure. Centuries ago, Hippocrates listed a number of ailments that were more prevalent and specific to this season. Through the years, advanced research on nutrients, herbs and botanicals has given rise to a battery of supplement manufacturing services to help supplement business owners produce products that nutritionally assist the body’s natural functions for promoting health and wellness.

Which supplements are likely to receive more consumer attention? What are some of the fall 2011 nutraceutical manufacturing trends you’re likely to see? Here are a few common ailments associated with the fall season, as well the ingredients you can use to formulate supplements to potentially counter these ailments.

Respiratory ailments such as the common cold, flues and allergies are more prevalent when temperatures drop creating an environment more conducive to the growth of bacteria and virus. Rhinoviruses (common cold) and influenza virus (flu) are the most common invaders to the immune system. A 2010 research study in Australia showed that 70 percent of virus-related cold or flu symptoms and wheezing problems were associated with this particular virus. 1

Immune Boosting Ingredients:

  • Beta-glucans, a fiber-type of sugar compound present in oats, barley and yeast is known to enhance the functioning of the immune system. 2
  • While Vitamin C is historically known to promote immune health, a research study from Yale University shows that Vitamin D, the deficiency of which typically occurs in fall and winter, is associated with significantly reducing the duration of seasonal illnesses such as respiratory viral infections, including the flu, when compared to those with lower levels of Vitamin D. 3
  • Vitamin E also has demonstrated immune stimulating actions. A 2010 study conducted at Tufts University, Boston found that Vitamin E’s ability to lower respiratory infections was influenced by gender and gene factors. 4 Adequate levels of zinc have been associated with decreased risk of pneumonia and other infections. 5-7
  • Botanicals that contain Echinacea have been used traditionally for centuries to boost immune health. 8 Astragalus and elderberry demonstrate immune-stimulating properties. 9 Spirulina, a microalgae, is reported to increase resistance to infections and stimulate the production of antibodies and cytokines. 10

Stress and mental ailments such as certain melancholic and anxiety disorders are associated with changes in climate. Some people become gloomy as they consider the approaching winter months and yet others may be despondent because of current economic fears and uncertainties leading to sleepless nights and increased levels of anxiety. 11

The National Institute of Mental Health statistics show that major depressive disorder affects 6.7 percent of the U.S. population aged 18 and older (about 14.8 million adults). According to the World Health Report (2004), major depressive disorder is the leading cause of disability in the United States and Canada in ages 15-44. Anxiety disorders affect about 18.7 percent of adults (about 40 million individuals). 12-13

Anti-Stress Ingredients:

  • Several studies suggest that those who suffer from depression, anxiety and/or sleep disorders may benefit from taking St. John’s Wort. 14-15
  • Traditionally used as a sleeping aid, Valerian, a flowering plant, may help to relieve stress and anxiety and promote a general sense of well-being. Studies show that Passion Flower displays anti-anxiety properties. 16-17
  • Specialty ingredients such as cocoa polyphenols demonstrate mood-enhancing abilities as well as omega-3 fatty acids, particularly in women. L-theanine, an amino acid, found in green tea exhibits relaxing effects. 18-20

Joint pain – Cooler temperatures and changes in atmospheric pressure result in increased sensitivity, inflammation, rigidity and pain in joint articulations. But climatic changes in temperatures and humidity are not the only reasons for joint pain. The degeneration of the joints can be caused by obesity or the normal process of aging. About 50 million Americans suffer from some form of arthritis or rheumatic conditions, according to the National Center for Chronic Disease Prevention and Health Promotion. This chronic health problem is one of the most common causes of disability in the United States, limiting the activities of about 21 million adults. 21 The “U.S. Bone and Joint Health Ingredients Market,” from Frost & Sullivan (a global research firm) reported the market for joint health products earned revenues of more than $178.4 million in 2008 and predicts that by 2015, revenues will jump to $246 million. 22

Joint Health Supplement Ingredients:

  • Among the countless health benefits of omega-3 fatty acids, an intake of 3 to 4 months was seen to reduce joint pain intensity, minutes of morning stiffness, number of painful and/or tender joints and the use of NSAIDs. 23
  • Chondroitin sulfate, a structural component of cartilage, is a popular supplement for joint health, along with glucosamine. A research review conducted by World Health Organization (WHO) on randomized, placebo-controlled clinical trials published or performed between January 1980 and March 2002 supported the use of a combination of oral chondroitin sulfate and glucosamine for promoting joint health. 24-26
  • A natural multi-mineral ingredient, red seaweed, has shown positive effects on those who suffering from joint pain. 27 Methylsulfonylmethane (MSM), a compound of sulfur, demonstrates anti-inflammatory and antioxidant effects in the body. 28 Boswellia demonstrates anti-inflammatory actions. 29

Heart health problems may increase during fall due to swift changes in the temperature and atmospheric pressure resulting in the narrowing of arteries as the body tries to keep warm. A study from Scotland shows cardiovascular-related hospital admissions were related to temperature, with higher incidence occurring in the autumn/fall and early winter, particularly of elderly men. 30

About 81 million Americans, 1 in 3 adults, suffer from one or more types of cardiovascular disease (CVD) according to the American Heart Association. 31 In 2008, revenues for heart-health ingredients were reported at $563 million and are projected to exceed $2 billion by 2015 largely driven by aging baby boomers.

Heart-Health Ingredients:

  • In 2009, Frost & Sullivan drew attention to four heart-health ingredients including phytosterols, omega-3s, beta-glucans and soy protein.
  • Polyphenols found in cocoa have also demonstrated cholesterol-lowering properties and suggested efficacy in decreasing blood pressure, promoting healthy blood vessels. 32-33
  • CoQ10 is gaining prominence as a necessary nutrient for heart health management. 34
  • Grape seed extract shows benefits for promoting healthy blood pressure. 35
  • Studies show that resveratrol may inhibit low-density lipoprotein (LDL) oxidation and platelet aggregation, thus exhibiting cardio-protective benefits. 36

Digestive ailments, due to climatic changes, are particularly noted in children and the elderly during this season. Supplement business owners may want to anticipate greater consumer demand for probiotic and prebiotic supplements as well as digestive tonics that help improve a sluggish digestive system and its associated problems such as indigestion, constipation and flatulence.

Digestive Health Ingredients:

  • A combination of ginger and fennel may help soothe the gastrointestinal tract and treat mild digestive disorders. 37
  • Peppermint has carminative properties and may help stimulate digestion. 38
    Anise is commonly used to support digestion and has anti-flatulence properties.
  • Chamomile soothes the intestinal lining and also works as a mild laxative. 39
  • Herbs that may help to enhance nutrient assimilation and support the body’s natural detoxification process aloe vera extract, psyllium, senna, fructooligosaccharides (FOS) supports and promotes the overall health of gastrointestinal tract, Slippery Elm may help to alleviate gastric disturbances. 40-42
  • Milk thistle supports healthy digestion, alleviates mild digestive disorders and exhibits hepato-protective properties. 43
  • Cinnamon bark stimulates efficient digestion and helps to loosen up excess mucus during a cough, cold or sinus conditions. It promotes circulation and warmth and is particularly useful with the advent of cold weather. Studies also show cinnamon’s potential in reducing blood glucose levels. 44

Supplement Business Owners – Are You Ready with Fall Supplements?

Consumers enjoy the opportunity of managing their own health to combat seasonal ailments by choosing from an assortment of nutritional therapies. With our economy under continued stress and the anticipation of drastic healthcare reforms around the corner, consumers are more ready than ever to turn to well-researched dietary supplements to meet their health needs, as past trends have shown. 45-46

Nutricap Labs can quickly help you strategize your fall 2011 supplement manufacturing lineup in a variety of delivery forms such as capsules, tablets, powders, and softgels. Call (800) 494-6154 to speak with one of our Production Specialists or submit a request to receive a free quote to see how we can easily help you get high-quality supplement products off the ground quickly and efficiently to meet the challenging health needs of this season.


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2. Beta-glucan recognition by the innate immune system, Immunol Rev. 2009 Jul;230(1):38-50, PMID: 19594628. http://www.ncbi.nlm.nih.gov/pubmed/19594628

3. Serum 25-Hydroxyvitamin D and the Incidence of Acute Viral Respiratory Tract Infections in Healthy Adults. PLoS One. 2010 Jun 14;5(6):e11088.

4. IL-2 and IL-10 gene polymorphisms are associated with respiratory tract infection and may modulate the effect of vitamin E on lower respiratory tract infections in elderly nursing home residents. Am J Clin Nutr. 2010;92: 106-114.

5. Zinc: mechanisms of host defense. J Nutr. 2007 May;137(5):1345-9.

6. Serum zinc and pneumonia in nursing home elderly. Am J Clin Nutr. 2007 Oct;86(4):1167-73. Zinc supplementation decreases incidence of infections in the elderly: effect of zinc on generation of cytokines and oxidative stress. Am J Clin Nutr. 2007 Mar;85(3):837-44.

7. Efficacy and safety of echinacea in treating upper respiratory tract infections in children: a randomized controlled trial. J Pediatr. 2004 Jul;145(1):135-6.

8. The production of nitric oxide and prostaglandin E2 in peritoneal macrophages is inhibited by Andrographis paniculata, Angelica sinensis and Morus alba ethyl acetate fractions. J Ethnopharmacol. 2009 Feb 25;122(1):68-75.

9. Potential Health Benefits of Spirulina Microalgae: A review of Existing Literature. NUTRA foods. 2010;9(2):19-26.

10. Mental-Health Lines Buzz in U.S. Recession Depression (Update1), Rob Waters and David Olmos – September 19, 2008, Bloomberg, http://www.bloomberg.com/apps/news?sid=aEidcDQzs.U4&pid=newsarchive

11. NIMH: The numbers count – Mental disorders in America. National Institute of Health.

12. NIMH: The numbers count – Mental disorders in America. National Institute of Health. [Citing 2004 World Health Report Annex Table 3 Burden of disease in DALYs by cause, sex and mortality stratum in WHO regions, estimates for 2002. Geneva: World Health Organization]

13. Equivalence of St John’s wort extract (Ze 117) and fluoxetine: a randomized, controlled study in mild-moderate depression. Int Clin Psychopharmacol. 2000 Mar;15(2):61-8.

14. Acute treatment of moderate to severe depression with hypericum extract WS 5570 (St John’s wort): randomised controlled double blind non-inferiority trial versus paroxetine. BMJ. 2005 Mar 5;330(7490):503. Epub 2005 Feb 11.

15. Initial exploratory observational pharmacology of Valeriana wallichii on stress management: a clinical report. Nepal Med Coll J. 2007 Mar;9(1):36-9.

16. Passiflora for anxiety disorder, Cochrane Database Syst Rev. 2007 Jan 24;(1):CD004518.

17. Antidepressant-like effects of a cocoa polyphenolic extract in Wistar-Unilever rats. Nutr Neurosci. 2008 Dec;11(6):269-76.

18. Ethyl-eicosapentaenoic acid for the treatment of psychological distress and depressive symptoms in middle-aged women: a double-blind, placebo-controlled, randomized clinical trial. Am J Clin Nutr. 2009 Feb;89(2):641-51. Epub 2008 Dec 30.

19. The acute effects of L-theanine in comparison with alprazolam on anticipatory anxiety in humans, Hum Psychopharmacol. 2004 Oct;19(7):457-65.

20. Arthritis-Related Statistics, Center for Disease Control and Prevention http://www.cdc.gov/arthritis/data_statistics/arthritis_related_stats.htm#6

21. U.S. Bone and Joint Health Ingredients Market (May 2009), Frost & Sullivan. http://www.frost.com/sublib/display-report.do?id=N58B-01-00-00-00&bdata=bnVsbEB%2BQEJhY2tAfkAxNDA3NTA2Njc1NzI2

22. A meta-analysis of the analgesic effects of omega-3 polyunsaturated fatty acid supplementation for inflammatory joint pain, Pain, 2007 May;129(1-2):210-23. Epub 2007 Mar 1, PMID: 17335973. http://www.ncbi.nlm.nih.gov/pubmed/17335973

23. Glucosamine Sulfate Use and Delay of Progression of Knee Osteoarthritis, Arch Intern Med. 2002;162″2113-23

24. Combined glucosamine and chondroitin sulfate provides functional and structural benefit in the anterior cruciate ligament transection model, Clin Rheumatol. 2008 Sep 13. [Epub ahead of print]

25. Structural and Symptomatic Efficacy of Glucosamine and Chondroitin in Knee Osteoarthritis, Arch Intern Med. 2003;163(13):1514-22.

26. A natural mineral supplement provides relief from knee osteoarthritis symptoms: a randomized controlled pilot trial, Nutr J 2008;7:9 DOI:10.1186/1475-2891-7-9

27. Efficacy of methylsulfonylmethane (MSM) in osteoarthritis pain of the knee: a pilot clinical trial, Osteoarthritis Cartilage. 2006 Mar;14(3):286-94. Epub 2005 Nov 23. PMID: 16309928 http://www.ncbi.nlm.nih.gov/pubmed/16309928.

28. Boswellic acids in chronic inflammatory diseases. Planta Med. 2006 Oct;72(12):1100-16.

29. Seasonal variation in coronary heart disease in Scotland, J Epidemiol Community Health. 1995 Dec;49(6):575-82. PMID: 8596091 http://www.ncbi.nlm.nih.gov/pubmed/8596091

30. American Heart Association statistics, http://www.ssa.gov/compassionateallowances/cardiovascular/American Heart Association PowerPoint.ppt

31. US heart health product launches have tripled in five years

32. InvestFrost Chemicals – U.S. Heart Health Ingredients Market, April 2009, Frost & Sullivan, http://www.frost.com/prod/servlet/report-overview.pag?repid=N5AB-01-00-00-00

33. Short-term effect of cocoa product consumption on lipid profile: a meta-analysis of randomized controlled trials, Am J Clin Nutr. May 26, 2010

34. Improvement of Endothelial Function With Dietary Flavanols Is Associated With Mobilization of Circulating Angiogenic Cells in Patients With Coronary Artery Disease, J Am Coll Cardiol, 2010; 56:218-224

35. Coenzyme Q10, University of Maryland Medical Center.

36. Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome, Metabolism. 2009 Dec;58(12):1743-6

37. Resveratrol: a cardioprotective substance, Annals of the New York Academy of Sciences. Volume 1215, Resveratrol and Health pages 16-21, January 2011

38. The American Pharmaceutical Association Practical Guide to Natural Medicines, William Morrow and Company, Inc., Copyright 1999, pg. 288.

39. A review of the bioactivity and potential health benefits of peppermint tea (Mentha piperita L.). Phytother Res. 2006 Aug;20(8):619-33. Review.

40. Chamomile, Herbs at a Glance, National Institutes of Health, http://www.mayoclinic.org/drugs-supplements/aloe/background/hrb-20058665

41. Psyllium is superior to docusate sodium for treatment of chronic constipation, Aliment Pharmacol Ther. 1998 May;12(5):491-7, PMID: 9663731. http://www.ncbi.nlm.nih.gov/pubmed/9663731

42. The mechanism by which senna glycosides and related compounds stimulate peristalsis in the human colon. Wilkins JL, Hardcastle JD. PMID: 4921423

43. Digestion, excretion, and energy value of fructooligosaccharides in healthy humans. Am J Clin Nutr 1996, 64:324-328

44. Milk thistle and the treatment of hepatitis, Gastroenterol Nurs. 2001 Mar-Apr;24(2):95-7, PMID: 11847735. http://www.ncbi.nlm.nih.gov/pubmed/11847735.

45. The potential of cinnamon to reduce blood glucose levels in patients with type 2 diabetes and insulin resistance, Diabetes Obes Metab. 2009 Dec;11(12):1100-13. PMID: 19930003. http://www.ncbi.nlm.nih.gov/pubmed/19930003

46. Nutritional Supplements in the U.S., 4th Edition, Sept. 1, 2010, Packaged Facts, http://www.packagedfacts.com/Nutritional-Supplements-Edition-2642045/

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